The recent approval of first-line tyrosine kinase inhibitor plus immuno-oncology agent combination therapy for the treatment of advanced renal cell carcinoma offers substantially improved response rates and survival compared with the previous standard of care.
This expansion of treatment options has also led to a greater range and complexity of potential treatment-related adverse events related to overlapping toxicities. The aim of this article is to discuss the management of common treatment-emergent adverse events (AEs) associated with axitinib plus immuno-oncology therapy, highlight the specific roles of oncology nurses in managing these events, and provide AE management resources to aid oncology nurses in their care of patients with advanced renal cell carcinoma.
Author experience, journal articles, and treatment guidelines were used.
The use of oncology nurses and nurse-led innovations to monitor and assess treatments can have a positive impact on the management of AEs in cancer patients by identifying those who are most at risk, providing regular assessment, appropriate patient education, and supporting the monitoring of patient safety.
Skilled oncology nurses should be a key part of a team that addresses the supportive care needs and management of AEs that are associated with novel cancer treatments. Early and ongoing communication between the patient and oncology nurses regarding the development of adverse events is a critical component of maximizing treatment outcomes and quality of life.
Seminars in oncology nursing. 2023 Nov 25 [Epub ahead of print]
Sara Parreira, Kathleen Burns, Nancy Moldawer, Nazy Zomordian, Nesan Bandali, Kiran Virdee, Meghara Walsh, Daniel Kelly, Dharanija Rao, Rosemary Teresi, Laura S Wood
CUF Oncology, Lisbon, Portugal., Dana-Farber Cancer Institute, Massachusetts., Cedars Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, California., UCLA, Department of Urology, California., Sunnybrook Odette Cancer Centre, ON, Canada., Memorial Sloan Kettering Cancer Center, New York., Dana-Farber Cancers Institute, Massachusetts., Cardiff University, Wales, UK., Pfizer Inc., NY, USA., Pfizer Inc, NY, USA., Cleveland Clinic Cancer Center, Cleveland, Ohio (retired). Electronic address: .
PubMed http://www.ncbi.nlm.nih.gov/pubmed/38008655