We report an interesting case of testicular germ cell tumor with distinct seminomatous and teratomatous components.
A rare development of secondary somatic malignancy in the form of hepatocellular carcinoma was observed. Immunohistochemically, hepatocellular cancer was positive for cytokeratin, hepatocyte paraffin-1 (HepPar-1), α-fetoprotein, glypican-3 (GPC-3), octamer-binding transcription factor 3/4 (Oct3/4), and Ki-67. In addition, adenocarcinoma and rhabdomyoblastic differentiation were also evident. Placental alkaline phosphatase (PLAP), Sal-like 4, and Oct3/4 were positive in seminoma. To the best of our knowledge, we have not found any such report of secondary development of hepatocellular carcinoma in a testicular teratoma. We believe that it is a rare, distinct phenomenon in germ cell tumors and deserves recognition.
Written by:
Jain D, Mittal S, Gupta M. Are you the author?
Department of Pathology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India 110060 India.
Reference: Ann Diagn Pathol. 2012 Jul 2. Epub ahead of print.
doi: 10.1016/j.anndiagpath.2012.05.009
PubMed Abstract
PMID: 22763193
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