Background: The objective of this study was to assess markers of spermatogenesis in long-term survivors of testicular cancer (TC) according to treatment, and to explore correlations between the markers and associations with achieved paternity following TC treatment.
Methods:In 1191 TC survivors diagnosed between 1980 and 1994, serum-follicle stimulating hormone (s-FSH; n=1191), s-inhibin B (n=441), and sperm counts (millions per ml; n=342) were analysed in a national follow-up study in 1998-2002. Paternity was assessed by a questionnaire.
Results:At median 11 years follow-up, 44% had oligo- (< 15 millions per ml; 29%) or azoospermia (15%). Sperm counts and s-inhibin B were significantly lower and s-FSH was higher after chemotherapy, but not after radiotherapy (RT), when compared with surgery only. All measures were significantly more abnormal following high doses of chemotherapy (cisplatin (Cis)>850 mg, absolute cumulative dose) compared with lower doses (Cis ≤850 mg). Sperm counts were moderately correlated with s-FSH (-0.500), s-inhibin B (0.455), and s-inhibin B : FSH ratio (-0.524; all P< 0.001). All markers differed significantly between those who had achieved post-treatment fatherhood and those with unsuccessful attempts.
Conclusion:The RT had no long-term effects on the assessed markers of spermatogenesis, whereas chemotherapy had. At present, the routine evaluation of s-inhibin B adds little in the initial fertility evaluation of TC survivors.
Written by:
Brydøy M, Fosså SD, Klepp O, Bremnes RM, Wist EA, Bjøro T, Wentzel-Larsen T, Dahl O. Are you the author?
Section of Oncology, Institute of Medicine, University of Bergen, Bergen N-5021, Norway; Department of Oncology, Haukeland University Hospital, Bergen N-5021, Norway.
Reference: Br J Cancer. 2012 Nov 20;107(11):1833-9.
doi: 10.1038/bjc.2012.471
PubMed Abstract
PMID: 23169336
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