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- Sam Denmeade and Michael Schweizer join Charles Ryan at the 2019 Prostate Cancer Foundation Retreat (PCF 2019) to discuss testosterone replacement in advanced prostate cancer. The three discuss the impact of testosterone on prostate cancer cells, recent clinical trials involving testosterone replacement and the risks and benefits of adding this therapy to one’s treatment plan for prostate cancer p...
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- Piet Ost and Felix Feng discuss the role of the radiation oncologist with regards to recurrent disease after radiation therapy. The two radiation oncologists debated the different approaches of treating patients who have a local recurrence compared to patients who have regional distant metastasis. Biographies: Felix Feng, MD, Associate Professor of Radiation Oncology, Urology; and Medicine, Univer...
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- Susan Slovin joins Alicia Morgans to provide an update on the PRONOUNCE trial, the first Phase III prospective trial comparing a GnRH antagonist with a GnRH agonist with the endpoints of major adverse cardiovascular events. It explores how cardiovascular disease is not only affecting our patient's wellbeing on androgen deprivation therapy but also gives us for the first time a lot of different end...
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- Maha Hussain highlights the pearls in the treatment landscape of metastatic hormone-sensitive, castration-resistant, and non-metastatic castration-resistant disease that came out of the last few years in prostate cancer in terms of the evolution of therapeutics. She details a plethora of clinical trials that had led to significant clinical benefit for patients, primarily overall survival advantage...
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- Christopher Logothetis and Charles Ryan review key takeaways from Christopher Logothetis's Advanced Prostate Cancer Consensus Conference (APCCC 2019) presentation on Ethnicity and Prognosis of Prostate Cancer and the importance in understanding the differences in outcomes of individuals with the disease based on race and ethnicity. In his work Dr. Logothetis prepared for APCCC 2019, he presses the...
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- Deborah Mukherji sits down with Carmel Pezaro at the Advanced Prostate Cancer Consensus Conference (APCCC 2019) to share her perspective on how prostate cancer care in the Middle East, specifically Lebanon, compares to the rest of the globe. They discuss the impact and the potential of genomic testing and the use of novel imaging, such as PSMA PET/CT relevant to work in the Middle East and in Leba...
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- Ana Aparicio discusses her work with aggressive variant prostate cancer and her group’s research using immunohistochemistry results and genomic analysis to identify patients with a specific molecular signature. The research concludes that this molecular signature appears to identify the people that benefit from the addition of carboplatin to cabazitaxel chemotherapy. People that have the signature...
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- Matt Rettig discusses POPCaP and his work involving the health of veterans with prostate cancer and ongoing clinical trials going on exclusively within the Veterans Health Administration (VA) system. The Precision Oncology Program for Cancer of the Prostate (POPCaP), a partnership between the VA and the Prostate Cancer Foundation (PCF) to create a system of excellence for prostate cancer in VA is...
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- During the 2019 Advanced Prostate Cancer Consensus Conference (APCCC 2019), Susan Halabi joined Alicia Morgans to help interpret the various ongoing stage III clinical trials in prostate cancer. Dr. Halabi shares the top errors we can avoid in subgroup analyses. Biographies: Susan Halabi, Ph.D., Professor of Biostatistics and Bioinformatics, Duke Cancer Institute, Durham, North Carolina, United St...
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- Maria de Santis and Chuck Ryan share a conversation on the rapidly changing landscape for the treatment of locally advanced prostate cancer. A focus of the discussion centers around the STAMPEDE data demonstrating benefit with the early use of abiraterone and the use of radiation. They also discuss the role of docetaxel in this evolving environment based on data from both STAMPEDE and CHAARTED dat...
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