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- In this UroToday Journal Club, Zachary Klaassen reviews the Journal of clinical oncology publication entitled Long-Term Outcomes and Genetic Predictors of Response to Metastasis-Directed Therapy Versus Observation in Oligometastatic Prostate Cancer: Analysis of STOMP and ORIOLE Trials . The authors use two independent phase II trials, each of which enrolled men with oligometastatic prostate cancer...
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- In this UroToday Journal Club, Zachary Klaassen reviews the Nature Medicine publication entitled Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial. Nivo and ipi first demonstrated to have a benefit in this setting in the CheckMate 214 trial. However, the vast majority of patients still don't have a response, and...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen review the Lancet publication Adjuvant atezolizumab versus placebo for patients with renal cell carcinoma at increased risk of recurrence following resection (IMmotion010): a multicentre, randomised, double-blind, phase 3 trial. Approximately 80% of patients, present initially with local regional disease. However, despite the i...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen review The Lancet Oncology publication High-dose radiotherapy and risk-adapted androgen deprivation in localised prostate cancer (DART 01/05) looking at its 10-year results. Radiotherapy is a standard treatment option in patients with localized prostate cancer. With conventional dosing of radiotherapy, the addition of androgen...
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- In this UroToday Journal Club Christopher Wallis and Zach Klaassen highlight a JAMA oncology publication entitled Efficacy and Safety of Autologous Dendritic Cell-Based Immunotherapy, Docetaxel, and Prednisone vs Placebo in Patients With Metastatic Castration-Resistant Prostate Cancer: The VIABLE Phase 3 Randomized Clinical Trial. VIABLE sought to evaluate the efficacy and safety of DCVAC/PCa plus...
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- In this UroToday Journal Club Christopher Wallis and Zach Klaassen highlight a JAMA publication entitled the Effect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer. Symptom monitoring allows for the detection and treatment of symptoms, which may improve outcomes for cancer patients. The use of an electronic system to facilitate patient-reported o...
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- In this UroToday Journal Club Chris Wallis and Zach Klaassen highlight a Journal of Nuclear Medicine publication entitled Safety and Survival Outcomes of Lutetium-177-Prostate-Specific Membrane Antigen Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer with prior Radium-223 treatment: The RALU Study . The RAdium LUtetium (RALU) study evaluated the feasibility of sequential al...
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- Christopher Wallis and Zachary Klaassen discuss the results of the iROC trial, a JAMA publication titled the Effect of Robot-Assisted Radical Cystectomy With Intracorporeal Urinary Diversion vs Open Radical Cystectomy on 90-Day Morbidity and Mortality Among Patients With Bladder Cancer: A Randomized Clinical Trial . The iROC trial aimed to compare totally intracorporeal robotic assisted radical cy...
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- In this UroToday Journal Club video presentation Christopher Wallis and Zachary Klaassen highlight a The Lancet Oncology publication titled MRI-guided focused ultrasound focal therapy for patients with intermediate-risk prostate cancer: a phase 2b, multicentre study. A study which aimed to investigate whether MRI-guided focused ultrasound focal therapy can safely reduce treatment burden for patien...
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- In this UroToday Journal Club video presentation Drs Christopher Wallis and Zachary Klaassen highlight a Journal of Nuclear Medicine publication titled Predictors of 18F-DCFPyL PET/CT Positivity in Patients with Biochemical Recurrence of Prostate Cancer After Local Therapy which investigated the factors predicting scan positivity and disease location in patients with biochemical recurrence of pros...
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