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- In this UroToday Journal Club, Zachary Klaassen discusses the Journal of Clinical Oncology publication Sequencing of Androgen-Deprivation Therapy of Short Duration With Radiotherapy for Nonmetastatic Prostate Cancer (SANDSTORM): A Pooled Analysis of 12 Randomized Trials led by the MARCAP Consortium. The SANDSTORM meta-analysis evaluated the sequencing of short-term androgen deprivation therapy (AD...
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- In this UroToday Journal Club, Zachary Klaassen discusses the Lancet Oncology publication Patient-reported outcomes with olaparib plus abiraterone versus placebo plus abiraterone for metastatic castration-resistant prostate cancer: a randomised, double-blind, phase 2 trial. In this publication, the exploratory analysis of pain and health-related quality of life (HRQOL) is presented, looking at sig...
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- In this UroToday Journal Club, Zachary Klaassen highlights the PEACE-1 Lancet publication Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design. The efficacy and safety of abiraterone plus prednisone, with or without radi...
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- In this UroToday Journal Club, Zachary Klaassen highlights the International journal of cancer publication Abiraterone acetate plus prednisolone for metastatic patients starting hormone therapy: 5-year follow-up results from the STAMPEDE randomised trial. Abiraterone acetate plus prednisolone previously showed a clear survival advantage in men starting long-term hormone therapy for prostate cancer...
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- In this UroToday Journal Club, Zachary Klaassen highlights the JAMA oncology publication Disparities in the Inclusion of Racial and Ethnic Minority Groups and Older Adults in Prostate Cancer Clinical Trials: A Meta-analysis. Mandates have been put in place to emphasize both the importance of including racial and ethnic minorities in clinical trials and the reporting of the demographics of these tr...
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- In this UroToday Journal Club, Zachary Klaassen discusses the publication titled Shorter Radiation Regimens and Treatment Non-Completion Among Patients with Breast and Prostate Cancer in the United States: An Analysis of Racial Disparities in Access and Quality. The goal of this analysis is to assess trends in the uptake of shorter radiation regimes with a focus on the data for prostate cancer and...
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- Zachary Klaassen and Christopher Wallis dissect key updates to the NCCN Prostate Cancer Guidelines. Their focus lies on systemic therapy for mCRPC, specifically the latest modifications concerning PARP inhibitors. They reveal that men treated with androgen derivation therapy (ADT) for advanced prostate cancer will often progress to castration resistance. For those who reach this stage, continued A...
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- In this UroToday Journal Club, Zachary Klaassen highlights the European urology publication titled "Multiparametric Magnetic Resonance Imaging for the Detection of Clinically Significant Prostate Cancer: What Urologists Need to Know. Part 2: Interpretation." It is generally felt that MRI is superior to other imaging techniques, including CT scans, for soft tissue assessment. This data focuses on h...
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- In this UroToday Journal Club, Zachary Klaassen highlights the Journal of clinical oncology publication of the phase II SALV-ENZA Trial which sought to investigate whether enzalutamide, without concurrent androgen deprivation therapy, increases freedom from prostate-specific antigen progression when combined with salvage radiation therapy in men with recurrent prostate cancer after radical prostat...
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- In this UroToday Journal Club, Zachary Klaassen highlights the Urologic Oncology publication entitled Out-of-pocket costs for commercially insured patients with localized prostate cancer. Financial burdens may contribute to long-term effects on patient's health-related quality of life. However, costs are rarely included in shared decision-making conversations, and most studies available have focus...
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