- Details
- Zach Klaassen interviews Alicia Morgans about an edition focusing on prostate cancer survivorship in European Urology Focus. Morgans stresses the importance of survivorship and explains the diverse experiences of prostate cancer survivors, ranging from patients with low-grade cancer to those with incurable prostate cancer. The edition aims to address issues significant to these various populations...
|
- Details
- Derek Kang joins Alicia Morgans to discuss an ongoing exercise study focused on Black patients with prostate cancer undergoing Androgen Deprivation Therapy. This groundbreaking project is designed to study the potential effects of regular exercise on these patients' physical function, metabolic health, and prostate cancer outcomes. The study hopes to mitigate the higher risk of cardiovascular dise...
|
- Details
- Zach Klaassen hosts a high-level discussion with Christian Gratzke about the potential practice-changing outcomes of the EMBARK trial, specifically the impressive results of intensified treatment in high-risk patients. Dr. Gratzke suggests that intermittent hormone treatment could also be effective. The conversation also touches on enzalutamide monotherapy as a standalone treatment and how its suc...
|
- Details
- Samuel Washington and Randy Vince Jr delve into Vince’s publication, "Evaluation of Social Determinants of Health and Prostate Cancer Outcomes Among Black and White Patients: A Systematic Review and Meta-Analysis". The publication investigates racial disparities in prostate cancer outcomes, looking at societal factors—like environmental exposure and stress from trauma or racism—that can impact tum...
|
- Details
- Gavin Ha and Andrea Miyahira discuss Ha's research into the transcriptional regulation of advanced prostate cancer phenotypes. Dr. Ha's team uses circulating tumor DNA (ctDNA) in liquid biopsies to overcome challenges with traditional tumor biopsies in metastatic cancer patients. The focus of the research is on tumor phenotype, which may reveal why some tumors resist certain therapies. A new tool...
|
- Details
- Ruchika Talwar and Bashir Al Hussein Al Awamlh delve into contemporary trends of active surveillance versus definitive treatment in men with low-risk and favorable intermediate-risk prostate cancer. Their discourse revolves around a new article in JAMA Internal Medicine authored by Dr. Al Hussein, presenting evidence of increased adoption of active surveillance for such patients. The researchers f...
|
- Details
- Isla Garraway discusses the innovative strides being made in the Veterans Affairs (VA) system towards improving cancer care for veterans, particularly African-American vets. She details the success of initiatives like the partnership with the Prostate Cancer Foundation and the Precision Oncology Program, which facilitate critical genetic testing for veterans with metastatic prostate cancer. A sign...
|
- Details
- In this conversation, Alicia Morgans and Farnoosh Nik-Ahd discuss the diagnosis of prostate cancer in transgender women. Dr. Nik-Ahd highlights that despite gender affirmation surgeries, transgender women, who were assigned male at birth, retain their prostates and therefore remain at risk for prostate cancer. Using data collected from the Veterans Health Administration, she discusses the complexi...
|
- Details
- Andrea Miyahira speaks with Arianna Calcinotto and Nicolo Bancaro about their groundbreaking research on the role of senescent neutrophils in prostate cancer. Calcinotto's team discovered that prostate tumor cells produce a molecule, ApoE, which can bind to and influence a type of immune cells, neutrophils, resulting in these cells acquiring senescent, or aged features. They also found that these...
|
- Details
- In this discussion with Andrea Miyahira, Akash Patnaik illuminates the role of the Rb gene in severe forms of prostate cancer and its intriguing interaction with the immune system. His team's research uncovers that Rb loss is associated with lower immune infiltration and a higher presence of immunosuppressive genes. Patnaik's team further observes an unexpected upregulation of the STING gene, typi...
|
