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- Alexander Wyatt delves into his team's cutting-edge research on circulating tumor DNA (ctDNA) in relation to prostate cancer. This innovative study, published in Nature, elucidates the diversity and potential utility of ctDNA, found in the bloodstream, for understanding disease progression and characteristics. By developing algorithms to differentiate various ctDNA populations, they shed light on...
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- Noel Clarke delivers a comprehensive discussion about the STAMPEDE trial model, focusing on its innovative approach to prostate cancer treatment in the UK. He elaborates on the multi-arm, multi-stage (MAMS) trial design, emphasizing its flexibility and efficiency, and the collaboration with large data sets like the National Prostate Cancer Audit. Dr. Clarke highlights significant results, such as...
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- In this discussion between Alicia Morgans and Alexander Wyatt, the two delve into the complexities of using circulating tumor DNA (ctDNA) in the treatment of prostate cancer. Dr. Wyatt explains the advantages of ctDNA in the metastatic setting, highlighting its minimally invasive nature and ease of collection compared to tissue biopsy. He emphasizes the importance of timing and patient selection i...
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- Marzia Del Re discusses the complexity of tumor heterogeneity in prostate cancer, focusing on predictive biomarkers of resistance and response to therapy. Dr. Del Re emphasizes the high heterogeneity of prostate cancer from clinical, morphological, and molecular perspectives, highlighting the role of genetic and epigenetic alterations. She explores technological advancements like next-generation s...
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- Andrea Alimonti discusses the challenges and advancements in the understanding and treatment of castration-resistant prostate cancer (CRPC). Dr. Alimonti highlights his team's efforts to comprehend the mechanisms of CRPC initiation and progression and explores potential therapies that could reverse or treat CRPC using anti-tumor immune responses. He emphasizes his team's contributions to the field...
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- Julio Pelaitai recounts his journey with prostate cancer, which began with a surprise diagnosis following regular checkups. Initially, his prostate appeared healthy, but a subsequent rise in PSA levels led to a biopsy revealing high-grade malignant cells. Faced with options of surgery, radiation, or chemotherapy, Julio chose surgery, guided by his urologist. Post-surgery, elevated PSA levels indic...
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- Ignacio Calderón Balanzátegui shares his experience with prostate cancer, diagnosed three years ago at the age of 72. He underwent rapid surgery to remove his prostate, followed by minimal chemotherapy, as the cancer was caught early and had only slightly metastasized. Ignacio credits his prompt diagnosis and treatment to regular check-ups for his diabetes, which unexpectedly revealed a high PSA l...
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- Daniel Castellano emphasizes the importance of multidisciplinary approaches in patient care and research. He advocates for precision medicine in genitourinary tumors, highlighting advancements in prostate and bladder cancer treatments. Dr. Castellano stresses the need to overcome barriers in drug access and regulatory processes to provide better care. He expresses a strong connection with Argentin...
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- Gabriela Gatica discusses her experience as a woman in the male-dominated field of uro-oncology. Initially facing skepticism about working with male urologists and treating predominantly male patients, she found acceptance and success in her role. Dr. Gatica emphasizes the positive dynamics of interdisciplinary teamwork and encourages more women to join this fascinating specialty, aiming to increa...
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- Mauricio Fernández Lázaro discusses UroTarget, an annual conference in Mendoza that focuses on the interdisciplinary management of uro-oncological pathologies. The location fosters social interactions and networking among professionals, extending beyond scientific discussions to build friendships and strengthen interdisciplinary relations. Biographies: Mauricio Fernández Lázaro, MD Related Content...
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