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- Zach Klaassen hosts a discussion with Thomas Hope Jeremie Calais about a conference co-hosted by UCLA and UCSF, focusing on PSMA PET imaging and radioligand therapy. Scheduled for January 18th and 19th, 2024, at UCSF, the conference aims to educate healthcare professionals on interpreting PSMA PET results and managing patients effectively. The target audience includes both academic and private pra...
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- Alicia Morgans interviews Rana McKay about the upcoming second Annual Prostate Cancer Patient Summit at UCSD in February 2024. The summit, a collaboration between UCSD and the Prostate Cancer Foundation, aims to be a dynamic forum for patients, caregivers, and anyone interested in prostate cancer. The event will feature a community think tank to address unmet needs in prostate cancer research. Reg...
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- Tamara Jamaspishvili delves into her group's study on PTEN loss as an early predictor of prostate cancer metastasis post-surgery. The study employs artificial intelligence to enhance the accuracy of PTEN loss assessment, traditionally done manually by pathologists. Dr. Jamaspishvili explains that PTEN, a tumor suppressor gene, is a critical biomarker for aggressive prostate cancer. Her team's AI-b...
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- In this conversation, Andrea Miyahira hosts Gerhardt Attard to discuss a publication in Nature Communications, specifically focusing on the genomic architecture of lethal prostate cancer clones. The study from Dr. Attard’s team examines alterations in the androgen receptor (AR) and their association with resistance to treatments like abiraterone and enzalutamide. Dr. Attard highlights the intrapat...
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- Amina Zoubeidi delves into her research on prostate cancer lineage plasticity. She highlights her team’s paper, "ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer," published in Cell Reports. Dr. Zoubeidi explains the concept of lineage plasticity and its role in therapy resistance, particularly post-hormone therapy. She introduces th...
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- Scarlett Lin Gomez discusses the RESPOND study, which aims to understand the disproportionate impact of prostate cancer on African-American men. Dr. Gomez outlines the study's multi-level, socio-ecological approach, which integrates factors from structural racism and healthcare access to tumor biology. Funded by the NCI and the Prostate Cancer Foundation, the study has successfully recruited over...
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- Nima Sharifi presents a published paper that investigates the role of testosterone in prostate cancer. Over a decade-long study, Dr. Sharifi's team discovered that a subset of men undergoing radical prostatectomy have unusually high levels of periprostatic testosterone, linked to worse clinical outcomes such as PSA recurrence or salvage radiation therapy. This surprising finding challenges convent...
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- Daniela Brina discusses her team’s paper on prostate cancer pathways and the role of myeloid-derived suppressor cells (MDSCs) in tumor progression. The study delves into the extracellular interaction between prostate cancer and MDSCs, employing polysome profiling techniques across different genetic backgrounds. Dr. Brina and her team identified specific ligands and receptors that facilitate the re...
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- Andrea Miyahira hosts a discussion with Karen Sfanos about her group's research on Proliferative Inflammatory Atrophy (PIA) of the prostate, published in the Journal of Pathology. The paper, titled "Club-Like Cells in Proliferative Inflammatory Atrophy of the Prostate," investigates the relationship between PIA and prostate cancer, focusing on the abnormal proliferation of PIA cells resembling lun...
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- Andrea Miyahira hosts June Chan and Rebecca Graff to discuss their research on post-diagnostic health behaviors and their relation to prostate cancer progression and mortality. They reflect on two papers published in the British Journal of Cancer, examining factors such as smoking, obesity, physical activity, and BMI, and their impact on lethal prostate cancer. The conversation emphasizes that mai...
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