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- Matthew Rettig and Isla Garraway discuss the progress and aspirations of the Veterans Administration (VA) prostate cancer program, established through a Memorandum of Understanding with the Prostate Cancer Foundation. The program has expanded from six to 13 Centers of Excellence, with the VA committing $50 million to this initiative. Dr. Rettig emphasizes the program's focus on precision oncology,...
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- Leanne Woods-Burnham discusses her 2020 Young Investigator Award project with the Prostate Cancer Foundation, focusing on prostate cancer disparities, especially among black men. Her research looks at HER2 expression and its connection to West African ancestry. She explains that HER2 is correlated with this ancestry, rather than self-reported race. The project involves RNA sequencing on tumor tiss...
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- Alicia Morgans converses with Neeraj Agarwal about the ongoing phase III Contact-02 Trial, designed for patients with metastatic castrate-resistant prostate cancer (CRPC) who show disease progression on a novel hormonal therapy or androgen receptor inhibitor. Patients eligible for this trial should have measurable disease, which may include extra pelvic lymphadenopathy or visceral metastasis. Dr....
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- Alicia Morgans engages in a discussion with Mohamad Allaf about the PROSPER Study, an ECOG investigation focused on a neoadjuvant perioperative approach to treating high-risk kidney cancer. The conversation delves into the study's rationale and design, exploring the collaboration between medical oncologists and urologists. Dr. Allaf details the premise of the study, highlighting the implementation...
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- Rahul Aggarwal speaks with Alicia Morgans about the completed phase III trial AFT-19 for high-risk biochemically relapsed prostate cancer patients. The trial explored three arms: ADT alone, ADT plus apalutamide, and a triplet of ADT, apalutamide, and abiraterone, with a primary endpoint of PSA progression-free survival. Results showed significant prolongation of PSA progression-free survival in bo...
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- Alicia Morgans engages with Joaquin Mateo to discuss the clinically relevant challenges and approaches to somatic mutation testing in advanced prostate cancer patients. They address the difficulties in obtaining adequate tissue for testing, the concordance between different testing mechanisms, and the balance between ideal plans and clinical feasibility. Dr. Mateo emphasizes the importance of unde...
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- Alicia Morgans interviews Phil Kantoff to discuss the Prostate Cancer Foundation’s (PCF) evolution, significant achievements, and future directions. Dr. Kantoff recounts the early challenges of prostate cancer research, including the lack of funding and interest from the pharmaceutical industry. PCF's strategic initiatives, such as small grants and the Young Investigator Award, attracted a critica...
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- Charles Ryan and Howard Soule discuss the progress of the 2022 Prostate Cancer Foundation (PCF) TACTICAL Team Science Award campaign. The TACTICAL campaign, ( T herapy AC celeration T o I ntercept CA ncer L ethality) seeks qualified teams of academic scientists that will specifically address the development of 21st Century therapies for lethal forms of prostate cancer. These awards will be funded...
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- Howard Soule joins Charles Ryan as they discuss a new Prostate Cancer Foundation (PCF) TACTICAL Team Science Award as part of a broader novel T herapy AC celeration T o I ntercept CA ncer L ethality (TACTICAL) campaign. These larger team science awards will consist of $3MM or more team science awards seeking new therapies for treatment-resistant and intercepting issues of treatment resistance. One...
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- Alicia Morgans and David Quinn discuss the promotion of women through the ranks of medical oncology ensuring they have opportunities within the prostate cancer research and clinical arena. Biographies: David Quinn, MBBS, Ph.D., FR, Associate Professor of Medicine, Section Head, GU Oncology, Division of Cancer Medicine and Blood Diseases, Keck School of Medicine USC Alicia Morgans, MD, MPH , Genito...
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