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- Alan Bryce joins Alicia Morgans in a discussion on the interim overall survival data from TRITON3, a Phase 3 study comparing rucaparib to physician's choice of therapy in metastatic castration-resistant prostate cancer associated with homologous recombination deficiency. Eligible patients had received at least one prior androgen receptor pathway inhibitor, were chemotherapy-naïve in the CRPC setti...
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- This video provides a comprehensive overview of Decipher® Prostate, a genomic test used to personalize treatment for prostate cancer. In diagnosing prostate cancer, doctors traditionally assess the risk of the disease spreading based on three factors: the amount of disease in the prostate, the Gleason score, and a PSA blood test. However, these factors may lead to over or under-treatment of indivi...
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- Fred Saad joins Alicia Morgans in a discussion on the final overall survival data from the PROpel trial, a randomized controlled trial aimed to address the first-line mCRPC question in patients who have not been treated with a novel hormonal agent in the mCRPC setting. Patients were randomized to receive abiraterone and prednisone or abiraterone and olaparib. The trial's primary endpoint was radio...
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- Alicia Morgans converses with Noel Clarke about the significance of biomarkers in castration-resistant prostate cancer. Dr. Clarke highlights the clinical importance of recognizing diversity among prostate cancer patients, particularly considering age and associated comorbidities. Noting that many patients, especially from socially deprived backgrounds, face challenges due to comorbidities, he und...
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- Oliver Sartor and Alicia Morgans discuss the TRITON 3 clinical trial. TRITON 3 is a phase three clinical trial observing how patients with metastatic castration-resistant prostate cancer with a homologous recombination gene deficiency respond to treatment with rucaparib versus treatment with a physician’s choice of abiraterone, enzalutamide, or docetaxel. Results found that rucaparib improved radi...
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- In this discussion between Alicia Morgans and Alexander Wyatt, the two delve into the complexities of using circulating tumor DNA (ctDNA) in the treatment of prostate cancer. Dr. Wyatt explains the advantages of ctDNA in the metastatic setting, highlighting its minimally invasive nature and ease of collection compared to tissue biopsy. He emphasizes the importance of timing and patient selection i...
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- Jeffrey Ross speaks about the evolution and application of liquid biopsies in cancer treatment, including in cases of advanced metastatic breast cancer and prostate cancer. Drawing from his experience with circulating cancer cells, he details the development of circulating DNA and emphasizes the importance of precision medicine and personalized care. He contrasts liquid biopsies with tissue biopsi...
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- In this conversation, Alicia Morgans and Alan Bryce highlighted the TRITON3 study. TRITON3 is a Phase 3, multicenter, open-label, randomized trial of Rubraca in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC). The study enrolled 405 patients with a mutation in BRCA or ATM who were randomized to Rubraca or the control group, which consisted of the physician’...
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- At the 2022 Large Urology Group Practice Association (LUGPA) annual meeting, Emmanuel Antonarakis presented on Genetic and Genomic Testing in Prostate Cancer. Biography: Emmanuel Antonarakis, MD, Genitourinary Oncologist, Clark Endowed Professor of Medicine, Division of Hematology, Oncology and Transplantation, Associate Director of Translational Research, Masonic Cancer Center, The University of...
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- Fred Saad joins Alicia Morgans in a discussion focusing on the biomarker analysis and updated results from the Phase III PROpel trial of abiraterone and olaparib vs abiraterone and placebo as first-line therapy for patients with metastatic castration-resistant prostate cancer (mCRPC). This updated analysis provides more detail on patients with HRR mutations in the PROpel trial. In this biomarker a...
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