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- Maha Hussain is discussing the BRCAAway with Alicia Morgans, based upon Dr Hussain's presentation at ASCO 2022. The BRCAAway Trial is a randomized phase 2 trial of abiraterone, olaparib, or abiraterone + olaparib in patients with mCRPC with DNA repair defects either in the tumor or germline. The PARP-inhibitor olaparib is approved for mCRPC patients with deleterious germline or somatic homologous...
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- Oliver Sartor and Alicia Morgans delve into the complexities of implementing Lutetium-177 in clinical practices, especially amid recent supply chain issues. Dr. Sartor emphasizes the importance of multidisciplinary care and effective communication between medical oncologists and radiation oncologists for successful patient management. He outlines the licensure requirements and safety protocols nec...
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- Alicia Morgans speaks with Elena Castro and Colin Pritchard about the evolving role of molecular testing in treating men with prostate cancer. The discussion centers on the challenges and opportunities presented by recent data, particularly concerning combination therapies like Abiraterone and Olaparib. Dr. Pritchard emphasizes the importance of biomarkers in targeted therapies, while also acknowl...
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- Brittany Szymaniak sheds light on the critical role of germline genetic testing in prostate cancer. Dr. Szymaniak emphasizes that genetic testing is not just for metastatic cases but also for high-risk, very high-risk, and even localized disease. Patients with Ashkenazi Jewish ancestry and those with a family history of various cancers, including male breast cancer, should also be considered for t...
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- Alicia Morgans and Brenda Martone delve into the critical role of germline and somatic genetic testing in managing metastatic prostate cancer. Dr. Martone emphasizes the NCCN guidelines, which recommend offering both types of testing to patients with high-risk or metastatic disease. The conversation highlights the importance of family history and the broader implications of germline mutations, not...
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- Elena Castro and Joaquin Mateo join Alicia Morgans in a conversation on data related to genetic testing, PARP inhibitors, and the data we saw come out of GU ASCO with the PROpel and MAGNITUDE trials and they discuss how this data impacts the use of PARP inhibitors in castrate-resistant prostate cancer (CRPC). Drs. Castro, Mateo, and Morgans discuss this data in terms of next-generation sequencing...
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- Joining Alicia Morgans is Neal Shore to further highlight his team's presentation at this year's GU ASCO 2022 Annual Meeting focusing on evaluating the feasibility of instituting a hereditary cancer risk assessment (HCRA) protocol in their urological practice for prostate cancer patients. The results found were encouraging for the incorporation of recommended genomic screenings in community urolog...
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- Fred Saad joins Alicia Morgans to discuss the results of the PROpel phase 3 trial of olaparib and abiraterone versus placebo and abiraterone as first-line therapy for patients with metastatic castration-resistant prostate cancer (mCRPC). Biographies: Fred Saad, MD, FRCS, Professor and Chief of Urology, Director of GU Oncology, Raymond Garneau Chair in Prostate Cancer, University of Montreal Hospit...
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- Kara Maxwell and Alicia Morgans discuss DNA repair defect alterations in patients with localized prostate cancer. Dr. Maxwell highlights DNA repair in conjunction with prostate cancer, as well as the Penn Medicine BioBank. The conversation concludes with a discussion on the future of prostate cancer genomics. Biographies: Kara N. Maxwell, MD, Ph.D., Assistant Professor of Medicine and Genetics, Un...
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- In this LUGPA CME presentation, Dr Emmanuel Antonarakis discussed genomic profiling, germline, and somatic testing in the landscape of prostate cancer. He discusses what are germline mutations, what are somatic mutations, how common they are in prostate cancer as well as who should be tested for these mutations. Dr. Antonarakis guides the views through a genomics report, a next-generation sequenci...
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