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Advanced Bladder Cancer

Beyond Androgen Blockade - Exploring New Pathways for Treating mCRPC and mHSPC

APCCC 2024

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EMBARK

Recent Physician-Scientist Review Articles

  State of the Evidence Review Articles
Advanced Bladder Cancer
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PSMA-Targeted Therapy
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Transformative Evidence

  Curated by Clinicians: Educational Forum with Videos, Abstracts and Conference Information

ANKTIVA

  • Application covers 30 countries in the European Union
  • Submission is based on the ongoing QUILT 3.032 study in which 100 patients with Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer with carcinoma in situ (NMIBC CIS) have been treated with ANKTIVA® (nogapendekin alfa inbakicept-pmln) in combination with BCG, achieving a 71% (71/100) complete response (CR) rate
  • In these responders, the range of duration is 54 months and ongoing, exceeding all duration of response in approved products in this indication

ARANOTE

Presented by Niven Mehra, MD
The 2024 ESMO annual meeting included a session on prostate cancer, featuring a discussion presentation by Dr. Niven Mehra discussing three abstracts including “Efficacy and safety of darolutamide plus ADT in patients with mHSPC from the phase 3 ARANOTE trial” by Dr. Fred Saad, “Prostate cancer efficacy results from a randomized phase 3 evaluation of transdermal estradiol versus LHRH agonists for androgen suppression in M0 prostate cancer” by Dr. Ruth Langley, and “Phenotypic and genomic characterization of de novo metastatic prostate cancer: an ancillary study of the PEACE-1 phase 3 trial” by Dr. Cedric Pobel.

Trials in Progress

  Curated by Clinicians: Educational Forum with Videos, Abstracts and Conference Information

CORE-008 Trial

Presented by Trinity J. Bivalacqua, MD, PhD
 The 2024 SUO annual meeting included a urothelial carcinoma session, featuring a presentation by Dr. Trinity Bivalacqua discussing CORE-008, a phase 2, multi-arm, multi-cohort, open-label study to evaluate the safety and efficacy of cretostimogene grenadenorepvec in participants with high-risk non-muscle invasive bladder cancer (NMIBC).