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Advanced Bladder Cancer

Beyond Androgen Blockade - Exploring New Pathways for Treating mCRPC and mHSPC

APCCC 2024

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Advanced Bladder Cancer
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  Curated by Clinicians: Educational Forum with Videos, Abstracts and Conference Information

ANKTIVA

  • Application covers 30 countries in the European Union
  • Submission is based on the ongoing QUILT 3.032 study in which 100 patients with Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer with carcinoma in situ (NMIBC CIS) have been treated with ANKTIVA® (nogapendekin alfa inbakicept-pmln) in combination with BCG, achieving a 71% (71/100) complete response (CR) rate
  • In these responders, the range of duration is 54 months and ongoing, exceeding all duration of response in approved products in this indication

ARANOTE

Presented by Niven Mehra, MD
The 2024 ESMO annual meeting included a session on prostate cancer, featuring a discussion presentation by Dr. Niven Mehra discussing three abstracts including “Efficacy and safety of darolutamide plus ADT in patients with mHSPC from the phase 3 ARANOTE trial” by Dr. Fred Saad, “Prostate cancer efficacy results from a randomized phase 3 evaluation of transdermal estradiol versus LHRH agonists for androgen suppression in M0 prostate cancer” by Dr. Ruth Langley, and “Phenotypic and genomic characterization of de novo metastatic prostate cancer: an ancillary study of the PEACE-1 phase 3 trial” by Dr. Cedric Pobel.

Trials in Progress

  Curated by Clinicians: Educational Forum with Videos, Abstracts and Conference Information

CLARIFY Trial

  • Two abstracts on Clarity’s diagnostic COBRA and CLARIFY trials with 64Cu-SAR-bisPSMA have been accepted for presentation at the American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU) 2025.
  • An abstract on the COBRA study has also been selected for presentation at the American Urological Association (AUA) Annual Meeting 2025.
  • The data to be presented shows that 64Cu-SAR-bisPSMA identifies more lesions and at earlier timepoints than currently approved prostate-specific membrane antigen (PSMA) positron emission tomography (PET) agents, and with a high true positivity rate based on histopathology assessment. Lesions <5 mm in size were identified by 64Cu-SAR-bisPSMA in 14% of participants (including lesions in the 2 mm range).
  • The early identification and detection of lesions can inform treatment selection and impact the outcomes for prostate cancer patients.

Reno, Nevada (UroToday.com) -- Clarity Pharmaceuticals (ASX: CU6) (“Clarity” or “Company”), a clinical-stage radiopharmaceutical company with a mission to develop next-generation products that improve treatment outcomes for children and adults with cancer, is pleased to announce the acceptance of two abstracts for presentation at the ASCO GU 2025 Conference on Clarity’s COBRA and CLARIFY trials and an abstract on the COBRA trial at the AUA Annual Meeting 2025. These conferences are among the world’s most prestigious in oncology and urology, and the acceptance of these abstracts is testament to the strength of Clarity’s data and the exciting prospects for the diagnostic 64Cu-SAR-bisPSMA to change the paradigm in the diagnosis and treatment of cancer.

CORE-008 Trial

Presented by Trinity J. Bivalacqua, MD, PhD
 The 2024 SUO annual meeting included a urothelial carcinoma session, featuring a presentation by Dr. Trinity Bivalacqua discussing CORE-008, a phase 2, multi-arm, multi-cohort, open-label study to evaluate the safety and efficacy of cretostimogene grenadenorepvec in participants with high-risk non-muscle invasive bladder cancer (NMIBC).