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Leaders in Radiopharmaceuticals: Disruptive Innovations and Personal Perspectives
- Imaging the Immune System: CD8 T-Cell Tracking for Cancer and Autoimmune Disease - Anna Wu
- Covalent Radioligands Advance Precision in Tumor Targeting - Andreas Goutopoulos
- Lead-212 Radiopharmaceuticals Offer Promise in Targeted Cancer Treatment - Volker Wagner View all Leaders in Radiopharmaceuticals: Disruptive Innovations and Personal Perspectives videos
LUGPA 2024
- Integrating New Technologies into Everyday Practice Management "Presentation" - Neal Patel, Mark Thompson, Candice Sonko & Alicia Davis
- Leveraging Cutting-Edge Technologies to Enhance Prostate Cancer Treatments "Presentation" - Scott Eggener
- Incorporating New Approaches for Evaluating, Diagnosing, and Treating BPH "Presentation" - Kevin McVary, Timothy McClure & Kevin Zorn View all LUGPA 2024 videos
Managing Small Renal Masses in Renal Cell Carcinoma Videos
- The Value and Limitations of Biopsies for Small Renal Masses - Phillip Pierorazio
- Advancing Imaging Techniques for Small Renal Mass Diagnosis and Clinical Decision-Making - Sam Chang
- Functional Renal Imaging and Advances in Kidney Cancer Detection - Shankar Siva View all Managing Small Renal Masses in Renal Cell Carcinoma Videos videos
Featured Videos
PIVOT-006: Phase III Trial of Creto vs Surveillance in Intermediate-Risk Bladder Cancer - Mark Tyson
PEACE 3 Trial Results Show Promise for Radium-223 and Enzalutamide in Asymptomatic mCRPC - Fred Saad
Durvalumab Plus Guadecitabine in Metastatic Kidney Cancer: Phase 1/2 Trial Results - Yousef Zakharia
Access and Utilization of Healthcare by Adults with Spina Bifida - Lindsay Hampson & Alejandro Lopez
Probing the Promising Future of Anti-HER2 Therapies for Micropapillary Bladder Cancer - Jeffrey Ross
Quality of Life and Patient-relevant Endpoints With Darolutamide in the ARASENS Trial - Karim Fizazi
A Urologist's Perspective on PSMA-Radioligand Therapy in the Treatment Setting of mCRPC - Neal Shore
Association of Inherited Mutations in DNA Repair Genes with Localized Prostate Cancer – Kara Maxwell
The Stakeholders in Operationalizing an Integrated PSMA Imaging and Therapies Clinic - Kendra Harris
Patient Selection for ADT Treatment with the Oral GnRH Antagonist in Clinical Practice - Ashley Ross
Genomic Classifier in Prostate Cancer: High-Risk
High-Risk Non-Muscle Invasive Bladder Cancer
Advanced Bladder Cancer
Integrating (177Lu)–PSMA-617: A Practical Approach for Urology Clinics
Beyond Androgen Blockade - Exploring New Pathways for Treating mCRPC and mHSPC
APCCC 2024
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EMBARK
Recent Conference Coverage
Conference Highlights Written by Physician-Scientist
2024 Society of Urologic Oncology (SUO) Annual Meeting
- SUO 2024: Biomarkers and Clinical Predictors in RCC
- SUO 2024: Update on Neoadjuvant Therapy Trials in RCC
- SUO 2024: Joseph A Smith, Jr. Mentorship Award Lecture
South-Central Section of the American Urological Association SCS AUA 2024
- SCS AUA 2024: Financial Toxicity in Testicular Cancer Treatment, Validated Questionnaire Correlated Software Cost Modeling
- SCS AUA 2024: Multiparametric MRI in the Evaluation of Small Renal Masses
- SCS AUA 2024: Pelvic Exenteration and Urologic Complications: A 90-Day Audit of the Practice at a Single Tertiary Level Medical Center
Recent Physician-Scientist Review Articles
State of the Evidence Review Articles
Advanced Bladder Cancer
- The Quickly Evolving Treatment Landscape of Metastatic Urothelial Carcinoma: A New Standard of Care in First-Line Systemic Therapy
Written by Zachary Klaassen, MD, MSc Associate Professor of Urology Urologic Oncologist Medical College of Georgia, Georgia Cancer Center Augusta, GA and Rashid Sayyid, MD, MSc Urologic Oncology Fellow University of Toronto Toronto, Ontario, Canada
- The Treatment Landscape of Metastatic Urothelial Carcinoma: Second-Line Systemic Therapy
Written by Zachary Klaassen, MD, MSc Associate Professor of Urology Urologic Oncologist Medical College of Georgia, Georgia Cancer Center Augusta, GA and Rashid Sayyid, MD, MSc Urologic Oncology Fellow University of Toronto Toronto, Ontario, Canada
PSMA-Targeted Therapy
- Beyond a VISION to Making a SPLASH: Advances in PSMA-Based Theranostics in Prostate Cancer
Written by Zachary Klaassen, MD, MSc, Medical College of Georgia, Augusta, Georgia
Transformative Evidence
Curated by Clinicians: Educational Forum with Videos, Abstracts and Conference Information
ANKTIVA
ImmunityBio Announces European Medicines Agency Acceptance of Marketing Authorization Application for ANKTIVA® for the Treatment of Patients with BCG-Unresponsive Non-Muscle Invasive Bladder Cancer Carcinoma In Situ- Application covers 30 countries in the European Union
- Submission is based on the ongoing QUILT 3.032 study in which 100 patients with Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer with carcinoma in situ (NMIBC CIS) have been treated with ANKTIVA® (nogapendekin alfa inbakicept-pmln) in combination with BCG, achieving a 71% (71/100) complete response (CR) rate
- In these responders, the range of duration is 54 months and ongoing, exceeding all duration of response in approved products in this indication
ARANOTE
ESMO 2024: Invited Discussant: Phase 3 ARANOTE Trial, Phase 3 Evaluation of Transdermal Estradiol vs LHRH Agonists and Ancillary Study of the PEACE-1
Presented by Niven Mehra, MD
The 2024 ESMO annual meeting included a session on prostate cancer, featuring a discussion presentation by Dr. Niven Mehra discussing three abstracts including “Efficacy and safety of darolutamide plus ADT in patients with mHSPC from the phase 3 ARANOTE trial” by Dr. Fred Saad, “Prostate cancer efficacy results from a randomized phase 3 evaluation of transdermal estradiol versus LHRH agonists for androgen suppression in M0 prostate cancer” by Dr. Ruth Langley, and “Phenotypic and genomic characterization of de novo metastatic prostate cancer: an ancillary study of the PEACE-1 phase 3 trial” by Dr. Cedric Pobel. Read More
Trials in Progress
Curated by Clinicians: Educational Forum with Videos, Abstracts and Conference Information
CLARIFY Trial
Clarity to Present COBRA and CLARIFY Abstracts at Two World-Leading Conferences- Two abstracts on Clarity’s diagnostic COBRA and CLARIFY trials with 64Cu-SAR-bisPSMA have been accepted for presentation at the American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU) 2025.
- An abstract on the COBRA study has also been selected for presentation at the American Urological Association (AUA) Annual Meeting 2025.
- The data to be presented shows that 64Cu-SAR-bisPSMA identifies more lesions and at earlier timepoints than currently approved prostate-specific membrane antigen (PSMA) positron emission tomography (PET) agents, and with a high true positivity rate based on histopathology assessment. Lesions <5 mm in size were identified by 64Cu-SAR-bisPSMA in 14% of participants (including lesions in the 2 mm range).
- The early identification and detection of lesions can inform treatment selection and impact the outcomes for prostate cancer patients.
Reno, Nevada (UroToday.com) -- Clarity Pharmaceuticals (ASX: CU6) (“Clarity” or “Company”), a clinical-stage radiopharmaceutical company with a mission to develop next-generation products that improve treatment outcomes for children and adults with cancer, is pleased to announce the acceptance of two abstracts for presentation at the ASCO GU 2025 Conference on Clarity’s COBRA and CLARIFY trials and an abstract on the COBRA trial at the AUA Annual Meeting 2025. These conferences are among the world’s most prestigious in oncology and urology, and the acceptance of these abstracts is testament to the strength of Clarity’s data and the exciting prospects for the diagnostic 64Cu-SAR-bisPSMA to change the paradigm in the diagnosis and treatment of cancer. Read More
CORE-008 Trial
SUO 2024: CORE-008: A Phase 2, Multi-Arm, Multi-Cohort, Open-Label Study to Evaluate the Safety and Efficacy of Cretostimogene Grenadenorepvec in Participants with High-Risk NMIBC
Presented by Trinity J. Bivalacqua, MD, PhD
The 2024 SUO annual meeting included a urothelial carcinoma session, featuring a presentation by Dr. Trinity Bivalacqua discussing CORE-008, a phase 2, multi-arm, multi-cohort, open-label study to evaluate the safety and efficacy of cretostimogene grenadenorepvec in participants with high-risk non-muscle invasive bladder cancer (NMIBC). Read More